High Potency Protease
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چکیده
High Potency Protease is a concentrated source of protease enzymes, which have been shown to improve protein digestion, reduce inflammation and speed the healing of wounds, inhibit the formation of blood clots, protect against intestinal parasitic infection and the overgrowth of yeast, and support immune function. High Potency Protease also contains bentonite, a concentrated source of minerals and trace nutrients—all enzyme activities involve minerals.1,2
منابع مشابه
Darunavir: an overview of an HIV protease inhibitor developed to overcome drug resistance.
Darunavir (TMC114) is a second-generation, sulfonamide, nonpeptidic protease inhibitor (PI) with a unique, flexible, 3-dimensional structure that contributes to it high potency and slow selection of resistant virus. Darunavir has to be coadministered with low-dose ritonavir and food to optimize its pharmacokinetics. Ritonavir-boosted darunavir is effective in many heavily pretreated patients, i...
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Tremendous strides were made in reducing the morbidity and mortality associated with HIV infection with the introduction of protease inhibitor (PI) therapy. However, limitations in the tolerability and potency of initial PIs quickly emerged. The development of newer agents in this class attempts to address these concerns, offering less frequent dosing, lower pill burdens, and increased potency ...
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The structures of both native and S139A holo-HCV NS3/4A protease domain were solved to high resolution. Subsequently, structures were determined for a series of ketoamide inhibitors in complex with the protease. The changes in the inhibitor potency were correlated with changes in the buried surface area upon binding the inhibitor to the active site. The largest contributions to the binding ener...
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Darunavir (formerly TMC114) is a second-generation, sulfonamide-based, peptidomimetic protease inhibitor (PI) with a modified 3-dimensional structure enabling more efficient binding to HIV protease. It has become an important drug, in combination with low-dose ritonavir boosting, in the treatment of both antiretroviral-naïve and multiclass-experienced patients. Growing data now exist suggesting...
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